Innovative Nano-Composite Biomimetic Scaffold for Osteo-Chondral Tissue Regeneration
نویسندگان
چکیده
Introduction Osteo-chondral articular defects still represent a key concern in modern orthopaedic surgery and several techniques have been so far proposed (1). A novel strategy able to promote cartilage and sub-chondral bone regeneration of full-thickness defects was recently developed, consisting on implantation of a three-layered nano-composite biomimetic scaffold. This peculiar structure mimics the osteocartilaginous tissue compartment (cartilage, tide-mark and sub-chondral bone), thanks to Mg-HA nano-crystals nucleation on type I collagen fibers during their self-assembling (2). The scaffold has been object of an intense chemical-physical characterization, followed by a pilot clinical study, in order to verify its regenerative performances.
منابع مشابه
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